Medscape - Seizure, Lennox-Gastaut syndrome-specific dosing for Lamictal, Lamictal XR (lamotrigine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy. Lamotrigine may be taken with or without food or on a full or empty stomach. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed. This article describes the dosages of Lamictal, as well as its strengths and how to take it. To learn more about Lamictal, see this in-depth article. Detailed dosage guidelines and administration information for Lamictal (lamotrigine). Includes dose adjustments, warnings and precautions. The decrease in dose of LAMICTAL should not exceed 25% of the total daily dose per week over a 2-week period, unless clinical response or lamotrigine plasma levels indicate otherwise [see. Lamotrigine helps manage seizures and symptoms of bipolar 1 disorder. Here are typical lamotrigine dosages for adults, and what to do if you miss a dose. Detailed Lamotrigine dosage information for adults and children. Includes dosages for Bipolar Disorder, Epilepsy and Lennox-Gastaut Syndrome; plus renal, liver and dialysis adjustments. Whether 100mg of lamotrigine is a significant dose depends on an individual’s condition and their doctor’s recommendation. For epilepsy, the usual adult dose ranges from 100mg to 700mg daily, while younger children have weight-dependent doses. Maximum Dosing of Lamotrigine (Lamictal) The maximum dose of lamotrigine is 500 mg/day for epilepsy, with typical maintenance dosing of 200-300 mg/day, and 200 mg/day for bipolar disorder. 1, 2, 3 The decrease in dose of 131 LAMICTAL should not exceed 25% of the total daily dose per week over a 2-week period, 132 unless clinical response or lamotrigine plasma levels indicate otherwise.